Police were called to the scene just before 5 p.m. on Morningside Dr., between Fairy Ave. and Hearne Ave. More than a dozen units remained on the scene as of 6:45 p.m.
Police say one child was playing with a gun and discharged it. A 4-year-old boy was shot in the chest and died. The 3-year-old girl was transported to Oschner with a gunshot wound to her arm. Police have not yet released her condition.
Two adults were in the home at the time, according to officers.